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Submit ReviewTemozolomide
说明： DNA-methylating antitumor agent
别名： NSC 362856,CCRG 81045
化学名： 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
纯度： ≥99% (HPLC)
生物活性 for Temozolomide
Temozolomide is a DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 μM for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).
化合物库 for Temozolomide
Temozolomide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Temozolomide
| 分子量 | 194.15 |
| 公式 | C6H6N6O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 85622-93-1 |
| PubChem ID | 5394 |
| InChI Key | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
| Smiles | CN1N=NC2=C(N=CN2C1=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Temozolomide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.71 | 50 |
制备储备液 for Temozolomide
以下数据基于产品分子量 194.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.3 mL | 51.51 mL | 103.01 mL |
| 2.5 mM | 2.06 mL | 10.3 mL | 20.6 mL |
| 5 mM | 1.03 mL | 5.15 mL | 10.3 mL |
| 25 mM | 0.21 mL | 1.03 mL | 2.06 mL |
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产品说明书 for Temozolomide
参考文献 for Temozolomide
参考文献是支持产品生物活性的出版物。
Plowman et al (1994) Preclinical antitumor activity of temozol. in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 54 3793 PMID: 8033099
Clark et al (1995) Antitumor imidazotetraazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozol. J.Med.Chem. 38 1493 PMID: 7739008
Bodell et al (2003) Formation of DNA adducts and induction of lacI mutations in big blue rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric tumors. Cancer Epidemiol.Biomarkers Prevent. 12 545 PMID: 12815001
Kanzawa et al (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11 448 PMID: 14713959
If you know of a relevant reference for Temozolomide, please let us know.
关键词: Temozolomide, Temozolomide supplier, DNA-methylating, antitumor, agent, Apoptosis, Inducer, NSC362856, CCRG81045, chemotherapeutics, TMZ, NSC, 362856, CCRG, 81045, Inducers, Autophagy, 2706, Tocris Bioscience
6 篇 Temozolomide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Temozolomide 的部分引用包括：
Johannessen et al (2013) The DNA repair protein ALKBH2 mediates temozol. resistance in human glioblastoma cells. Neuro Oncol 15 269 PMID: 23258843
Hu et al (2012) Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res 72 3873 PMID: 22665268
Canello et al (2014) Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. PLoS One 9 e113854 PMID: 25460932
Pastori et al (2014) BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics 9 611 PMID: 24496381
Deng et al (2017) Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther 360 215 PMID: 27821713
Prabhu et al (2013) Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA. PLoS One 7 e52265 PMID: 23284962
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Temozolomide 的评论
平均评分: 5 (Based on 1 Review.)
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Generating TMZ-resistant glioma cell lines.
By
MARINA KOUTSIOUMPA on 10/18/2022
分析类型： In Vitro
种属： Human
Temozolomide was used for the establishment of TMZ-resistant glioma cell lines.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Temozolomide
