主页 / 药理学 / Enzymes / Ligases / Ubiquitin E3 Ligases / Tenovin-1

Tenovin-1

Cat. No. 3365 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3365 has been discontinued.

View all Ubiquitin E3 Ligases products.
说明： Protects against MDM2-mediated p53 degradation
化学名： N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 说明书 参考文献

生物活性 for Tenovin-1

Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

技术数据 for Tenovin-1

分子量 369.48
公式 C20H23N3O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 380315-80-0
PubChem ID 1013376
InChI Key WOWJIWFCOPZFGV-UHFFFAOYSA-N
Smiles CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C)=O)C=C2)=S)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Tenovin-1

参考文献是支持产品生物活性的出版物。

Lain et al (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454 PMID: 18455128

按标靶查看相关产品

关键词: Tenovin-1, Tenovin-1 supplier, activators, p53, transcriptional, activity, Protects, against, MDM2-mediated, degradation, Transcription, Factors, Ligases, Ubiquitin, E3, 3365, Tocris Bioscience

1 篇 Tenovin-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Tenovin-1 的部分引用包括：

Hackett et al (2019) Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. MBio 10 PMID: 31289184

Tenovin-1 的评论

目前没有该产品的评论。 Be the first to review Tenovin-1 and earn rewards!

Have you used Tenovin-1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia