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TG 003

Cat. No. 4336 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B
化学名： (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TG 003

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

化合物库 for TG 003

TG 003 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TG 003

分子量 249.33
公式 C13H15NO2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 719277-26-6
PubChem ID 647991
InChI Key BGVLELSCIHASRV-UHFFFAOYSA-N
Smiles O=C(C)/C=C1SC2=CC=C(OC)C=C2N\1CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TG 003

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.93 100
ethanol 18.7 75

制备储备液 for TG 003

以下数据基于产品分子量 249.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.11 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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产品说明书 for TG 003

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TG 003

参考文献是支持产品生物活性的出版物。

Muraki et al (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 279 24246 PMID: 15010457

Foucourt et al (2014) Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 19 15411 PMID: 25264830

If you know of a relevant reference for TG 003, please let us know.

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关键词: TG 003, TG 003 supplier, TG003, ATP-competitive, Cdc2-like, inhibitors, inhibits, Clk, Clk-family, kinases, DYRK1A, DYRK1B, DYRK1A/B, CLK, (Cdc2-like, kinases), DYRK, 4336, Tocris Bioscience

1 篇 TG 003 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TG 003 的部分引用包括：

Lucas et al (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559 211-216 PMID: 29973724

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