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说明： High affinity cereblon fluorescent probe
化学名： 2-((1E,3E)-5-((E)-1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate
纯度： ≥90% (HPLC)
生物活性 for Thalidomide-Cyanine 5
Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
Optical Data for Thalidomide-Cyanine 5
| Emission Color | Red |
|---|---|
| λabs | 650 nm |
| λem | 665 nm |
| Closest Laser line | 647 nm |
| Application | TR-FRET |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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技术数据 for Thalidomide-Cyanine 5
| 分子量 | 1041.2 |
| 公式 | C52H60N6O13S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| InChI Key | RWTYSFWRLGGPLR-UHFFFAOYSA-N |
| Smiles | O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(OCC(NCCCCNC(CCCCCN(C(C=CC(S(=O)(O)=O)=C4)=C4C/5(C)C)C5=C\C=C\C=C\C6=[N+](CC)C7=C(C=C(S(=O)([O-])=O)C=C7)C6(C)C)=O)=O)=C31)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Thalidomide-Cyanine 5
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.82 | 20 |
制备储备液 for Thalidomide-Cyanine 5
以下数据基于产品分子量 1041.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 4.8 mL | 24.01 mL | 48.02 mL |
| 1 mM | 0.96 mL | 4.8 mL | 9.6 mL |
| 2 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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产品说明书 for Thalidomide-Cyanine 5
参考文献 for Thalidomide-Cyanine 5
参考文献是支持产品生物活性的出版物。
Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012
Petzold et al (2016) Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase. Nature 532 127 PMID: 26909574
Cavadini et al (2016) Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 531 598 PMID: 27029275
Chessum et al (2018) Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766). J.Med.Chem. 61 918 PMID: 29240418
If you know of a relevant reference for Thalidomide-Cyanine 5, please let us know.
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关键词: Thalidomide-Cyanine 5, Thalidomide-Cyanine 5 supplier, thalidomide, fluorescent, probes, time-resolved, fluorescence, resonance, energy, transfer, TR-FRET, cereblon, E3, ligases, Ubiquitin, Ligases, Enzyme, Probes, and, Substrates, FP, Assay, Reagents, 7288, Tocris Bioscience
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