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Thalidomide

Cat. No. 0652 12 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Binds cereblon; also TNF-α synthesis inhibitor
化学名： N-(2,6-dioxo-3-piperidinyl)phthalimide
纯度： ≥99% (HPLC)
说明书
引用文献 (12)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Thalidomide

Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

技术数据 for Thalidomide

分子量 258.23
公式 C13H10N2O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 50-35-1
PubChem ID 5426
InChI Key UEJJHQNACJXSKW-UHFFFAOYSA-N
Smiles O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Thalidomide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.46 25

制备储备液 for Thalidomide

以下数据基于产品分子量 258.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 15.49 mL 77.45 mL 154.9 mL
1.25 mM 3.1 mL 15.49 mL 30.98 mL
2.5 mM 1.55 mL 7.75 mL 15.49 mL
12.5 mM 0.31 mL 1.55 mL 3.1 mL

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参考文献 for Thalidomide

参考文献是支持产品生物活性的出版物。

Boireau et al (1997) Thal. reduces MPTP-induced decrease in striatal DA levels in mice. Neurosci.Lett. 234 123 PMID: 9364513

Kanbayashi et al (1996) Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881 PMID: 8905685

Makonkawkeyoon et al (1993) Thal. inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 90 5974 PMID: 8327469

Zhang et al (2008) Thal. influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 27 60 PMID: 18983651

Sampaio et al (1991) Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699 PMID: 1997652

Merck Index 12 9390

Ito et al (2010) Identification of a primary target of Thal. teratogenicity. Science 327 1345 PMID: 20223979

Donovan et al (2018) Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223

Li et al (2021) Network bioinformatics analysis provides insight into drug repurposing for COVID-2019. Med.Drug Discov. 10 PMID: 33817623

If you know of a relevant reference for Thalidomide, please let us know.

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关键词: Thalidomide, Thalidomide supplier, TNF-α, TNF-alpha, alfa, synthesis, inhibitors, inhibits, Tumor, Necrosis, Factor-α, Cytokines, Signaling, Signalling, angiogenesis, teratogen, anti-inflammatory, cereblon, ubiquitin, E3, ligase, modulator, CELMoD, SALL4, SARS-Cov-2, COVID-19, coronaviruses, Antiangiogenics, Ubiquitin, Ligases, Other, Transcription, Factors, Molecular, Glues, 0652, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

12 篇 Thalidomide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Thalidomide 的部分引用包括：

Rocha et al (2006) Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br J Pharmacol 148 688 PMID: 16702985

Kannappan et al (2010) γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. J Biol Chem 285 33520 PMID: 20720018

Gu et al (2010) Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model. Mol Pain 6 64 PMID: 20923560

Pandey et al (2010) Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer 127 282 PMID: 19937797

Sandur et al (2010) 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res 8 107 PMID: 20068065

Prete et al (2016) Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem 291 17209 PMID: 27325702

Girgis et al (2010) Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line. MBio 1 663 PMID: 22966360

Ahn et al (2007) Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 110 2286 PMID: 17609425

Pathak et al (2007) Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5 943 PMID: 17855663

Sung et al (2009) Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model. Mol Cancer Ther 8 959 PMID: 19372569

Eter and Spitznas (2002) DMSO mimics inhibitory effect of Thal. on choriocapillary endothelial cell proliferation in culture. Oncol Lett 86 1303 PMID: 12386094

Helmy et al (2015) Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032

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