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Tilfrinib

Cat. No. 5579 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective breast tumor kinase (Brk) inhibitor
化学名： 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Tilfrinib

Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.

许可信息

Sold under license from Martin-Luther-Universität-Halle-Wittenburg

化合物库 for Tilfrinib

Tilfrinib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Tilfrinib

分子量 275.3
公式 C17H13N3O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1600515-49-8
PubChem ID 76332983
InChI Key RXPZOSHFGJWSLQ-UHFFFAOYSA-N
Smiles OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Tilfrinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.53 100

制备储备液 for Tilfrinib

以下数据基于产品分子量 275.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for Tilfrinib

参考文献是支持产品生物活性的出版物。

Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948 PMID: 24650640

If you know of a relevant reference for Tilfrinib, please let us know.

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关键词: Tilfrinib, Tilfrinib supplier, potent, selective, breast, tumor, kinases, Brk, antiproliferative, cancer, tyrosine-protein, 6, TK6, inhibitors, inhibits, Src, Kinases, 5579, Tocris Bioscience

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