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TL 0259

Cat. No. 6981 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable
化学名： 3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TL 0259

TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.

许可信息

Sold under license from Dana-Farber Cancer Institute

化合物库 for TL 0259

TL 0259 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TL 0259

分子量 682.56
公式 C32H34F3N5O4.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2415263-06-6
InChI Key AMHWQBGAKJESFB-UHFFFAOYSA-N
Smiles CCN1CCN(CC1)CC2=C(C(F)(F)F)C=C(C=C2)NC(C3=CC=C(C(OC4=NC=NC5=C4C=C(C(OC)=C5)OC)=C3)C)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TL 0259

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.13 50

制备储备液 for TL 0259

以下数据基于产品分子量 682.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.93 mL 14.65 mL 29.3 mL
2.5 mM 0.59 mL 2.93 mL 5.86 mL
5 mM 0.29 mL 1.47 mL 2.93 mL
25 mM 0.06 mL 0.29 mL 0.59 mL

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参考文献 for TL 0259

参考文献是支持产品生物活性的出版物。

Weir et al (2018) Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. ACS Chem.Biol. 13 1551 PMID: 29763550

If you know of a relevant reference for TL 0259, please let us know.

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关键词: TL 0259, TL 0259 supplier, TL0259, Fgr, Lyn, Src, family, nonreceptor, tyrosine, kinases, inhibitors, inhibits, potent, selective, orally, bioavailable, Kinases, 6981, Tocris Bioscience

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