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Trovafloxacin mesylate

Cat. No. 3863 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antibiotic; inhibits bacterial DNA synthesis
别名： CP 99219
化学名： 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Trovafloxacin mesylate

Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Trovafloxacin mesylate

Trovafloxacin mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Trovafloxacin mesylate

分子量 512.46
公式 C20H15F3N4O3.CH3SO3H
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 147059-75-4
PubChem ID 62960
InChI Key DYNZICQDCVYXFW-GIPYJWDTSA-N
Smiles O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Trovafloxacin mesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 25.62 50
DMSO 51.25 100

制备储备液 for Trovafloxacin mesylate

以下数据基于产品分子量 512.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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产品说明书 for Trovafloxacin mesylate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Trovafloxacin mesylate

参考文献是支持产品生物活性的出版物。

Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615 PMID: 7872757

Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691 PMID: 9124824

Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329 PMID: 24646995

If you know of a relevant reference for Trovafloxacin mesylate, please let us know.

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关键词: Trovafloxacin mesylate, Trovafloxacin mesylate supplier, CP99219, antibiotics, antibacterial, antimicrobial, DNA, topoisomerase, IV, gyrase, dna, synthesis, inhibitors, inhibits, Pfizer, CP, 99219, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Topoisomerase, Gap, Channels, 3863, Tocris Bioscience

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Hepatoxic side effects of Trovafloxacin was studied against other several quinolones.
By Anonymous on 12/15/2019
种属： Human

Hepatoxic side effects of Trovafloxacin was studied against other several quinolones (temafloxacin, sparfloxacin, grepafloxacin, trovafloxacin) which have been withdrawn or their use severely limited soon after their clinical introduction owing to severe and sometimes life-threatening adverse events.

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该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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