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TW 37

Cat. No. 4038 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4038 has been discontinued.

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说明： Bcl-2 inhibitor; induces apoptosis
化学名： N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TW 37

TW 37 is a Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.

技术数据 for TW 37

分子量 573.7
公式 C33H35NO6S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 877877-35-5
PubChem ID 11455910
InChI Key PQAPVTKIEGUPRN-UHFFFAOYSA-N
Smiles OC1=C(CC2=C(C(C)C)C=CC=C2)C=C(C(NC3=CC=C(S(C4=C(C(C)(C)C)C=CC=C4)(=O)=O)C=C3)=O)C(O)=C1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TW 37

参考文献是支持产品生物活性的出版物。

Wang et al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139 PMID: 17034116

Zeitlin et al (2006) Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66 8698 PMID: 16951185

Ashimori et al (2009) TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol.Cancer.Ther. 8 893 PMID: 19372562

Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757 PMID: 19318573

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关键词: TW 37, TW 37 supplier, bcl-2, inhibitors, inhibits, proapoptotic, apoptosis, inducers, TW37, Bcl-2, Family, Apoptosis, Inducers, 4038, Tocris Bioscience

1 篇 TW 37 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TW 37 的部分引用包括：

Majeed et al (2019) Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug FBT in VEGF-dependent angiosarcomas in vitro. Sci Rep 9 6316 PMID: 31004117

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