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Submit ReviewTWS 119
Discontinued Product
This product has been withdrawn from sale and is superseded by TWS 119 (Cat. No. 7405)
说明： GSK-3β inhibitor; induces neuronal differentiation in ESCs
化学名： 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate
纯度： ≥98% (HPLC)
生物活性 for TWS 119
TWS 119 is an inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
技术数据 for TWS 119
| 分子量 | 546.38 |
| 公式 | C18H14N4O2.2CF3CO2H |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1507095-58-0 |
| PubChem ID | 90488884 |
| InChI Key | XJEFPMFFWJTJSL-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C(O)=O.OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.FC(F)(F)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TWS 119
参考文献 for TWS 119
参考文献是支持产品生物活性的出版物。
Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632
Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116
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关键词: TWS 119, TWS 119 supplier, TWS119, stem, cells, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, inhibitors, inhibits, neuronal, differentiation, Glycogen, Synthase, Kinase, 3, ESCs, and, iPSC, Neural, Stem, Cells, 3835, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for TWS 119
