TWS 119

Cat. No. 7405 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

化学名： 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

纯度： ≥97% (HPLC)

说明书

引用文献

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TWS 119

TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC₅₀ = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC₅₀ = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.

化合物库 for TWS 119

TWS 119 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TWS 119

分子量	318.33
公式	C₁₈H₁₄N₄O₂
储存	Store at +4°C
纯度	≥97% (HPLC)
CAS Number	601514-19-6
PubChem ID	9549289
InChI Key	VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Smiles	OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TWS 119

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	31.83	100
	ethanol	1.59	5

制备储备液 for TWS 119

以下数据基于产品分子量 318.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.71 mL	31.41 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for TWS 119

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TWS 119

参考文献是支持产品生物活性的出版物。

Zeng et al (2009) Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem.Biophys.Res.Commun. 391 1049 PMID: 19995556

Gattinoni et al (2009) Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962

Forget et al (2012) Stimulation of Wnt/β-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype. PLoS One 7 e41074 PMID: 22859966

If you know of a relevant reference for TWS 119, please let us know.

按标靶查看相关产品

关键词: TWS 119, TWS 119 supplier, TWS119, potent, glycogen, synthase, kinases, inhibitors, neuronal, differentiation, stem, cells, T-cells, tcells, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, Glycogen, Synthase, Kinase, 3, ESCs, and, iPSC, Neural, Stem, Cells, 7405, Tocris Bioscience

篇 TWS 119 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TWS 119 的引用文献。您是否知道使用了 Tocris TWS 119 的优秀论文？请告知我们.

TWS 119 的评论

目前没有该产品的评论。 Be the first to review TWS 119 and earn rewards!

Have you used TWS 119?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

Self-renewal and Maintenance
Differentiation
Reprogramming
Organoid Generation
GMP and Ancillary Material Grade Products

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TWS 119

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.