Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewU0124
说明： Inactive analog of U0126 (Cat. No. 1144)
化学名： Bis[amino(methylthio)methylene]butanedinitrile
生物活性 for U0124
U0124 is an inactive analog of U0126 (Cat. No. 1144). Does not inhibit MEK at concentrations up to 100 μM. Used as a negative control.
Active Analog also available.
技术数据 for U0124
| 分子量 | 226.31 |
| 公式 | C8H10N4S2 |
| 储存 | Store at RT |
| CAS Number | 108923-79-1 |
| PubChem ID | 5842955 |
| InChI Key | LBQNBMSPTURKGS-KQQUZDAGSA-N |
| Smiles | N/C(SC)=C(\C(C#N)=C(SC)/N)/C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U0124
参考文献 for U0124
参考文献是支持产品生物活性的出版物。
Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623 PMID: 9660836
Fitzgerald (2000) Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 527 433 PMID: 10990531
Sekar et al (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by Ins and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated pro Endocrinology 142 2921 PMID: 11416012
按标靶查看相关产品
按产品操作查看相关产品
关键词: U0124, U0124 supplier, Mitogen-Activated, Protein, Kinase, kinases, MEK, 1868, Tocris Bioscience
9 篇 U0124 的引用文献
引用文献是使用了 Tocris 产品的出版物。 U0124 的部分引用包括：
Huang et al (2010) Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci 30 6080 PMID: 20427666
Kolber et al (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci 30 8203 PMID: 20554871
Bentley et al (2011) Influence of chylomicron remnants on human monocyte activation in vitro. Skelet Muscle 21 871 PMID: 20674313
Philips et al (2013) MAPK establishes a molecular context that defines effective training patterns for long-term memory formation. Nutr Metab Cardiovasc Dis 33 7565 PMID: 23616561
Melemedjian et al (2011) Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain 7 70 PMID: 21936900
Melemedjian et al (2013) mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 154 1080 PMID: 23607966
Ye et al (2012) Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia. Proc Natl Acad Sci U S A 109 18162 PMID: 23071303
Chen-Roetling et al (2009) Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology 56 922 PMID: 19371583
Liverman et al (2009) Oestrogen increases nociception through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of allodynia. Cephalalgia 29 520 PMID: 19210515
U0124 的评论
目前没有该产品的评论。 Be the first to review U0124 and earn rewards!
Have you used U0124?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for U0124
