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Urolithin A

Cat. No. 6762 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
化学名： 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Urolithin A

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

技术数据 for Urolithin A

分子量 228.2
公式 C13H8O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1143-70-0
PubChem ID 5488186
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
Smiles OC1=CC=C2C(OC(C3=CC(O)=CC=C23)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Urolithin A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.82 100

制备储备液 for Urolithin A

以下数据基于产品分子量 228.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.91 mL 43.82 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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产品说明书 for Urolithin A

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Urolithin A

参考文献是支持产品生物活性的出版物。

Totiger et al (2019) Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 18 301 PMID: 30404927

Yuan et al (2016) Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 7 26 PMID: 26559394

If you know of a relevant reference for Urolithin A, please let us know.

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关键词: Urolithin A, Urolithin A supplier, UrolithinA, AKt, PI, 3-kinase, PI3K, signaling, inhibitor, inhibits, anticancer, neuroprotectant, protein, kinase, B, PKB, amyloid, beta, β, A-beta, Akt, (Protein, Kinase, B), 3-Kinase, Amyloid, Beta, Peptides, 6762, Tocris Bioscience

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Pathways for Urolithin A

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.