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VL 285

Cat. No. 7903 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： VHL inhibitor
化学名： (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥97% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VL 285

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

技术数据 for VL 285

分子量 532.66
公式 C29H32N4O4S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1448188-57-5
PubChem ID 71667162
InChI Key HEDFFPYRFJKXQP-VJTSUQJLSA-N
Smiles CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VL 285

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.63 50
ethanol 10.65 20

制备储备液 for VL 285

以下数据基于产品分子量 532.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.75 mL 18.77 mL 37.55 mL
2.5 mM 0.75 mL 3.75 mL 7.51 mL
5 mM 0.38 mL 1.88 mL 3.75 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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参考文献 for VL 285

参考文献是支持产品生物活性的出版物。

Buckley et al (2015) HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem.Biol. 10 1831 PMID: 26070106

Xiao et al (2022) Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 601 434 PMID: 34937944

If you know of a relevant reference for VL 285, please let us know.

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关键词: VL 285, VL 285 supplier, VL285, von, hippel, lindau, ligand, E3, ubiquitin, ligase, inhibitor, inhibitors, inhibits, VHL, degradation, Ubiquitin, Ligases, 7903, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia