WYE 687 dihydrochloride

Cat. No. 4282 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective mTOR inhibitor

化学名： N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for WYE 687 dihydrochloride

WYE 687 dihydrochloride is a potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC₅₀ = 7 nM). Displays selectivity for mTOR over PI 3-Kα (~100-fold) and PI 3-Kγ (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G₁ cell cycle arrest and selective apoptosis.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for WYE 687 dihydrochloride

WYE 687 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for WYE 687 dihydrochloride

分子量	601.53
公式	C₂₈H₃₂N₈O₃2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1702364-87-1
PubChem ID	90488926
InChI Key	ZQJPHAXLAKKXIX-UHFFFAOYSA-N
Smiles	O=C(OC)NC(C=C4)=CC=C4C1=NC(N3CCOCC3)=C2C(N(C5CCN(CC6=CN=CC=C6)CC5)N=C2)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WYE 687 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	60.15	100
	DMSO	60.15	100

制备储备液 for WYE 687 dihydrochloride

以下数据基于产品分子量 601.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.31 mL	16.62 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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产品说明书 for WYE 687 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WYE 687 dihydrochloride

参考文献是支持产品生物活性的出版物。

Yu et al (2009) Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer.Res. 69 6232 PMID: 19584280

If you know of a relevant reference for WYE 687 dihydrochloride, please let us know.

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1 篇 WYE 687 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WYE 687 dihydrochloride 的部分引用包括：

Saric et al (2016) mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Data Brief 27 321 PMID: 26582390

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Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Glycolysis
Tricarboxylic Acid Cycle
Lipidogenesis
1C Metabolism and Nucleic Acid Synthesis
Drivers of Metabolic Reprogramming
pH and Redox Balance

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for WYE 687 dihydrochloride

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.