XL 413 hydrochloride

Cat. No. 5493 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective Cdc7 inhibitor

别名： BMS 863233

化学名： 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for XL 413 hydrochloride

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC₅₀ = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

技术数据 for XL 413 hydrochloride

分子量	326.18
公式	C₁₄H₁₂ClN₃O₂.HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	1169562-71-3
PubChem ID	67185304
InChI Key	UNDKJUKLBNARIZ-FVGYRXGTSA-N
Smiles	ClC1=CC=C2C(C(N=[C@@]([C@H]4NCCC4)NC3=O)=C3O2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XL 413 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	6.52	20

制备储备液 for XL 413 hydrochloride

以下数据基于产品分子量 326.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	15.33 mL	76.64 mL	153.29 mL
1 mM	3.07 mL	15.33 mL	30.66 mL
2 mM	1.53 mL	7.66 mL	15.33 mL
10 mM	0.31 mL	1.53 mL	3.07 mL

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产品说明书 for XL 413 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for XL 413 hydrochloride

参考文献是支持产品生物活性的出版物。

Sasi et al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300 PMID: 25412417

Koltun et al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727 PMID: 22560567

Azhagiri et al (2021) Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Res.Ther. 12 500 PMID: 34503562

If you know of a relevant reference for XL 413 hydrochloride, please let us know.

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