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YM 155

Cat. No. 6491 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Survivin suppressor
别名： sepantronium bromide
化学名： 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for YM 155

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

化合物库 for YM 155

YM 155 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for YM 155

分子量 443.29
公式 C20H19BrN4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 781661-94-7
PubChem ID 46931000
InChI Key OOLCTHGNPMKPRV-UHFFFAOYSA-M
Smiles COCCN1C(C)=[N+](C2=C1C(C3=CC=CC=C3C2=O)=O)CC4=NC=CN=C4.[Br-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for YM 155

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 44.33 100
DMSO 8.87 20

制备储备液 for YM 155

以下数据基于产品分子量 443.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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参考文献 for YM 155

参考文献是支持产品生物活性的出版物。

Iwasa et al (2008) Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res. 14 6496 PMID: 18927289

Premkumar et al (2013) Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther. 346 201 PMID: 23740602

Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520

If you know of a relevant reference for YM 155, please let us know.

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关键词: YM 155, YM 155 supplier, YM155, survivin, suppressor, inhibits, inhibitors, induces, apoptosis, sepantronium, bromide, ILF3, interleukin, enhancer, binding, factor, 3, inflammatory, pain, Inhibitor, of, Apoptosis, (IAP), DNA,, RNA, and, Protein, Synthesis, 6491, Tocris Bioscience

2 篇 YM 155 的引用文献

引用文献是使用了 Tocris 产品的出版物。 YM 155 的部分引用包括：

Serafini et al (2023) SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 16 eade4984 PMID: 37159520

Eric et al (2019) Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell 49 393-408.e7 PMID: 30982660

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for YM 155

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.