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Submit ReviewZM 336372
说明： Potent, selective c-Raf inhibitor
化学名： 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
纯度： ≥99% (HPLC)
生物活性 for ZM 336372
ZM 336372 is a potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM).
许可信息
Sold with the permission of AstraZeneca Ltd
化合物库 for ZM 336372
ZM 336372 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for ZM 336372
| 分子量 | 389.45 |
| 公式 | C23H23N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 208260-29-1 |
| PubChem ID | 5311006 |
| InChI Key | SCJNCDSAIRBRIA-DOFZRALJSA-N |
| Smiles | CN(C)C1=CC(=CC=C1)C(=O)NC1=CC=C(C)C(NC(=O)C2=CC=C(O)C=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ZM 336372
参考文献 for ZM 336372
参考文献是支持产品生物活性的出版物。
Hall-Jackson et al (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem.Biol. 6 559 PMID: 10421767
Wartenberg et al (2001) Down-regulation of intrinsic p-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J.Biol.Chem. 276 17420 PMID: 11279018
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关键词: ZM 336372, ZM 336372 supplier, Potent, selective, c-Raf, inhibitors, inhibits, Kinases, ZM336372, AstraZeneca, Raf, Kinase, 1321, Tocris Bioscience
4 篇 ZM 336372 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ZM 336372 的部分引用包括：
Alao et al (2006) Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. J Surg Res 5 40 PMID: 17018141
Deming et al (2010) ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines. J Neurosci 161 28 PMID: 20031160
Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213
Stockand (2003) Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am J Physiol Heart Circ Physiol 284 H176 PMID: 12388314
ZM 336372 的评论
平均评分: 5 (Based on 1 Review.)
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Used for Migration assays.
By
Anonymous on 07/01/2020
分析类型： In Vitro
种属： Human
细胞系/组织： A549 or MDAMB231
All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
