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Clofarabine

Cat. No. 2600 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Deoxycytidine kinase (dCK) substrate
Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Clofarabine

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Compound Libraries for Clofarabine

Clofarabine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Clofarabine

M. Wt 303.68
Formula C10H11ClFN5O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 123318-82-1
PubChem ID 119182
InChI Key WDDPHFBMKLOVOX-AYQXTPAHSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(N)=NC(Cl)=N2)[C@H]1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Clofarabine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.37 100

Preparing Stock Solutions for Clofarabine

The following data is based on the product molecular weight 303.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.93 mL
5 mM 0.66 mL 3.29 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for Clofarabine

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Clofarabine

References are publications that support the biological activity of the product.

Parker et al (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 51 2386 PMID: 1707752

Bonate et al (2006) Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov. 5 855 PMID: 17016426

Carson et al (1992) Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc.Natl.Acad.Sci.USA 89 2970

If you know of a relevant reference for Clofarabine, please let us know.

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Keywords: Clofarabine, Clofarabine supplier, Deoxycytidine, kinases, dCK, Enzyme, Substrates, activators, antimetabolites, chemotherapeutics, /, Activators, Other, Kinases, 2600, Tocris Bioscience

1 Citation for Clofarabine

Citations are publications that use Tocris products. Selected citations for Clofarabine include:

Xie et al (2012) Valproic acid synergistically enhances the cytotoxicity of clofar. in pediatric acute myeloid leukemia cells. Pediatr Blood Cancer 59 1245 PMID: 22488775

Do you know of a great paper that uses Clofarabine from Tocris? Please let us know.

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