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Submit ReviewAzoramide
Description: Unfolded protein response (UPR) modulator
Chemical Name: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Purity: ≥98% (HPLC)
Biological Activity for Azoramide
Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.
Technical Data for Azoramide
| M. Wt | 308.83 |
| Formula | C15H17ClN2OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 932986-18-0 |
| PubChem ID | 7518316 |
| InChI Key | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Azoramide
References for Azoramide
References are publications that support the biological activity of the product.
Fu et al (2015) Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci.Transl.Med. 7 292ra98 PMID: 26084805
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Citations for Azoramide
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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