PI 3-kinase

PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration.

The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDa catalytic subunit (3 forms in class 1A : α-, β- and δ- and one in class 1B : γ-). PI 3-kinases p110 α- and β- are ubiquitously expressed whilst p110 δ- expression is associated with leukocytes. Activating mutations in the p110α- subunit have recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes (C2α-, β- and γ-) that are sensitive to wortmannin (although less sensitive than Class I PI 3-kinases) but are resistant to LY 294002. Class III contains just one member, hVps34p, which is thought to play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.

External sources of pharmacological information for PI 3-kinase :

• BJP Guide

PI 3-Kinase Gene Data