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Submit ReviewAutophinib
Description: Potent VPS34 inhibitor
Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity: ≥98% (HPLC)
Biological Activity for Autophinib
Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).
Compound Libraries for Autophinib
Autophinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for Autophinib
| M. Wt | 346.73 |
| Formula | C14H11ClN6O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1644443-47-9 |
| PubChem ID | 129626605 |
| InChI Key | CEUMAXLRGBKFQP-UHFFFAOYSA-N |
| Smiles | CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Autophinib
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.93 | 20 |
Preparing Stock Solutions for Autophinib
The following data is based on the product molecular weight 346.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.42 mL | 72.1 mL | 144.2 mL |
| 1 mM | 2.88 mL | 14.42 mL | 28.84 mL |
| 2 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
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Product Datasheets for Autophinib
References for Autophinib
References are publications that support the biological activity of the product.
Richters et al (2015) Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 10 289 PMID: 25540906
Robke et al (2017) Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 56 8153 PMID: 28544137
If you know of a relevant reference for Autophinib, please let us know.
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Keywords: Autophinib, Autophinib supplier, Potent, autophagy, inhibitors, inhibits, VPS34, vacuolar, protein, sorting, 34, PI, 3-K, 3-kinase, Autophagy, 3-Kinase, 6324, Tocris Bioscience
1 Citation for Autophinib
Citations are publications that use Tocris products. Selected citations for Autophinib include:
Dominique et al (2021) TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Biochem J 478 3145-3155 PMID: 34405859
Do you know of a great paper that uses Autophinib from Tocris? Please let us know.
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