Casein Kinase 2

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory β-subunits and two catalytic units (α and α′) in a homomeric or heteromeric conformation.

Whilst the α- and α′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the α- and not the α′-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (Myc, Jun, NF-κB). CK2 is also thought to influence Wnt signaling via β-catenin phosphorylation, and the PI 3-K signaling pathway via the phosphorylation of Akt.

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Literature for Casein Kinase 2

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• Ubiquitin Proteasome Pathway
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Casein Kinase 2 (CK2) Gene Data