Home / Pharmacology / Enzymes / Kinases / Casein Kinase 2 / Casein Kinase 2 Inhibitors / TTP 22

TTP 22

Cat. No. 4432 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: High affinity, selective CK2 inhibitor
Chemical Name: 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TTP 22

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

Compound Libraries for TTP 22

TTP 22 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TTP 22

M. Wt 330.42
Formula C16H14N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 329907-28-0
PubChem ID 1536915
InChI Key RAOULLCLLOGTDA-UHFFFAOYSA-N
Smiles CC(C=C3)=CC=C3C1=CSC2=C1C(SCCC(O)=O)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TTP 22

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.04 100
ethanol 6.61 20

Preparing Stock Solutions for TTP 22

The following data is based on the product molecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

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References for TTP 22

References are publications that support the biological activity of the product.

Golub et al (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 46 870 PMID: 21276643

If you know of a relevant reference for TTP 22, please let us know.

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View all Casein Kinase 2 Inhibitors

Keywords: TTP 22, TTP 22 supplier, casein, kinase, 2, CK2, inhibits, inhibitors, selective, high, affinity, ATP, competitive, TTP22, Casein, Kinase, 4432, Tocris Bioscience

2 Citations for TTP 22

Citations are publications that use Tocris products. Selected citations for TTP 22 include:

Till S et al (2021) The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis. Commun Biol 4 336 PMID: 33712726

Didier Y R et al (2021) Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures. Elife 10 PMID: 34586063

Do you know of a great paper that uses TTP 22 from Tocris? Please let us know.

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Literature in this Area

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