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SGC CK2-1

Cat. No. 7450 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
Chemical Name: N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SGC CK2-1

SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC50 values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC50 = 440 nM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.

External Portal Information for SGC CK2-1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.

Compound Libraries for SGC CK2-1

SGC CK2-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SGC CK2-1

M. Wt 375.44
Formula C20H21N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2470424-39-4
PubChem ID 146681133
InChI Key YKDZIFFKQUNVHH-UHFFFAOYSA-N
Smiles CCC(NC1=C(C=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SGC CK2-1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.54 100

Preparing Stock Solutions for SGC CK2-1

The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for SGC CK2-1

References are publications that support the biological activity of the product.

Wells et al (2021) Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem.Biol. 28 546 PMID: 33484635

If you know of a relevant reference for SGC CK2-1, please let us know.

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Keywords: SGC CK2-1, SGC CK2-1 supplier, SGCCK2-1, SGCCK21, casein, kinases, inhibitors, CK2, CK2A2, CK2A1, DYRK2, potent, SGC, Casein, Kinase, 2, DYRK, 7450, Tocris Bioscience

1 Citation for SGC CK2-1

Citations are publications that use Tocris products. Selected citations for SGC CK2-1 include:

Carmine et al (2022) Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Sci Adv 8 eabo1215 PMID: 36044577

Do you know of a great paper that uses SGC CK2-1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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