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Description: Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
Purity: ≥98% (HPLC)
Biological Activity for A12B4C3
A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
Compound Libraries for A12B4C3
A12B4C3 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for A12B4C3
| M. Wt | 534.65 |
| Formula | C30H38N4O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1005129-80-5 |
| PubChem ID | 6610064 |
| InChI Key | KVHGJAKTBPFFNV-UHFFFAOYSA-N |
| Smiles | O=C2N(C4=CC=CC=C4)C(C1C=CC(C(O)CCCCCCCCCC)N(NC3=CC=C([N+]([O-])=O)C=C3)C12)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A12B4C3
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.47 | 100 |
Preparing Stock Solutions for A12B4C3
The following data is based on the product molecular weight 534.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.35 mL | 18.7 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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Product Datasheets for A12B4C3
References for A12B4C3
References are publications that support the biological activity of the product.
Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID: 19773431
Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID: 19940137
Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID: 22184240
If you know of a relevant reference for A12B4C3, please let us know.
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Keywords: A12B4C3, A12B4C3 supplier, Potent, selective, polynucleotide, kinases, phosphatases, PKNP, inhibitors, inhibits, DNA, repair, Other, Kinases, 5097, Tocris Bioscience
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