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Submit ReviewAmphotericin B
Description: Forms monovalent ion channels in lipid bilyers; antifungal
Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Purity: ≥90% (HPLC)
Biological Activity for Amphotericin B
Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal.
For more information about how Amphotericin B may be used, see our protocol:
3D Culture of Lung Alveolar CellsTechnical Data for Amphotericin B
| M. Wt | 924.09 |
| Formula | C47H73NO17 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 1397-89-3 |
| PubChem ID | 5280965 |
| InChI Key | APKFDSVGJQXUKY-INPOYWNPSA-N |
| Smiles | [H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Amphotericin B
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.48 | 20 |
Preparing Stock Solutions for Amphotericin B
The following data is based on the product molecular weight 924.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 5.41 mL | 27.05 mL | 54.11 mL |
| 1 mM | 1.08 mL | 5.41 mL | 10.82 mL |
| 2 mM | 0.54 mL | 2.71 mL | 5.41 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.08 mL |
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Product Datasheets for Amphotericin B
References for Amphotericin B
References are publications that support the biological activity of the product.
Muruglia et al (2019) Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 567 405 PMID: 30867598
Gallis et al (1990) Amphotericin B: 30 years of clinical experience. Rev.Infect.Dis. 12 308 PMID: 2184499
Lewis (2011) Current concepts in antifungal pharmacology. Mayo Clin.Proc. 86 805 PMID: 21803962
If you know of a relevant reference for Amphotericin B, please let us know.
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Keywords: Amphotericin B, Amphotericin B supplier, antifungal, monovalent, ion, channels, polyene, macrolide, Biochemicals, and, Molecular, Biology, Antifungals, 6930, Tocris Bioscience
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