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AZ 5704

Cat. No. 6330 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective ATM kinase inhibitor; orally bioavailable
Chemical Name: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZ 5704

AZ 5704 is a potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan (CPT 11, Cat. No. 2688) in tumor bearing, immunocompromised mice. Orally bioavailable.

Compound Libraries for AZ 5704

AZ 5704 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 5704

M. Wt 434.47
Formula C23H23FN6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1941214-06-7
PubChem ID 130470684
InChI Key XHNKFGYYGPLYPT-ZDUSSCGKSA-N
Smiles COCC1=NC=C(C2=CC3=C(N=CC(C(N)=O)=C3N[C@H](C4=NN(C=C4)C)C)C=C2F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ 5704

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.45 100

Preparing Stock Solutions for AZ 5704

The following data is based on the product molecular weight 434.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for AZ 5704

References are publications that support the biological activity of the product.

Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 59 6281 PMID: 27259031

If you know of a relevant reference for AZ 5704, please let us know.

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Citations for AZ 5704

Citations are publications that use Tocris products.

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Literature in this Area

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