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AZD 5363

Cat. No. 6978 Submit a Review Datasheet / COA / SDS
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Description: Potent pan-AKT inhibitor
Alternative Names: Capivasertib
Chemical Name: 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZD 5363

AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.

Compound Libraries for AZD 5363

AZD 5363 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 5363

M. Wt 428.92
Formula C21H25ClN6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1143532-39-1
PubChem ID 25227436
InChI Key JDUBGYFRJFOXQC-KRWDZBQOSA-N
Smiles NC1(CCN(CC1)C1=C2C=CNC2=NC=N1)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 5363

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.89 100

Preparing Stock Solutions for AZD 5363

The following data is based on the product molecular weight 428.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.31 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References for AZD 5363

References are publications that support the biological activity of the product.

Davies et al (2012) Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol.Cancer Ther. 11 873 PMID: 22294718

If you know of a relevant reference for AZD 5363, please let us know.

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Keywords: AZD 5363, AZD 5363 supplier, AZD5363, pan, AKT, inhibitors, inhibits, potent, orally, bioavailable, protein, kinase, B, PKB, Capivasertib, Akt, (Protein, Kinase, B), 6978, Tocris Bioscience

Citations for AZD 5363

Citations are publications that use Tocris products.

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Pathways for AZD 5363

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.