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Description: Selective calcium chelator
Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
Purity: ≥95% (HPLC)
Biological Activity for BAPTA
BAPTA is a selective calcium chelator.
Technical Data for BAPTA
| M. Wt | 476.44 |
| Formula | C22H24N2O10 |
| Storage | Store at +4°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 85233-19-8 |
| PubChem ID | 104751 |
| InChI Key | FTEDXVNDVHYDQW-UHFFFAOYSA-N |
| Smiles | OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=C(C=CC=C1)N(CC(O)=O)CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAPTA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| sodium bicarbonate (0.3N) | 4.76 | 10 |
Preparing Stock Solutions for BAPTA
The following data is based on the product molecular weight 476.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.99 mL | 104.95 mL | 209.89 mL |
| 0.5 mM | 4.2 mL | 20.99 mL | 41.98 mL |
| 1 mM | 2.1 mL | 10.49 mL | 20.99 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
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Product Datasheets for BAPTA
References for BAPTA
References are publications that support the biological activity of the product.
Hardie (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium 38 547 PMID: 16140375
If you know of a relevant reference for BAPTA, please let us know.
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Keywords: BAPTA, BAPTA supplier, Selective, Ca2+, chelator, calcium, Signaling, Signalling, Agents, General, Reagents, Calcium, Biochemicals, and, Molecular, Biology, 2786, Tocris Bioscience
17 Citations for BAPTA
Citations are publications that use Tocris products. Selected citations for BAPTA include:
Andrade-Talavera et al (2016) Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cereb Cortex 26 3637 PMID: 27282393
Cilz et al (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels. Cereb Cortex 24 3195 PMID: 23843440
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. PLoS One 6 e1791 PMID: 26086964
Vemana et al (2015) A critical role for the transient receptor potential channel type 6 in human platelet activation. Cell Commun Signal 10 e0125764 PMID: 25928636
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60 PMID: 24926236
Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967
Pick et al (2017) mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum. EMBO J 36 232 PMID: 27856517
Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730
Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534
Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Cell Death Dis 7 62 PMID: 25071439
Arozarena et al (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19 45 PMID: 21215707
Chefetz et al (2019) A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep 26 3061 PMID: 30865894
Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154 PMID: 23646190
Reneau et al (2009) Phorbol 12-myristate 13-acetate potentiation of N-MthD.-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. J Pharmacol Exp Ther 330 641 PMID: 19429793
Kaeser-Woo et al (2013) Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. J Neurosci 33 9769 PMID: 23739973
Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259 PMID: 22347811
Do you know of a great paper that uses BAPTA from Tocris? Please let us know.
Reviews for BAPTA
Average Rating: 5 (Based on 1 Review.)
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Study of remote regulation of calcium ions.
By
Lutpine Rachel on 01/02/2020
Species: Human
In order to permit remote regulation of Ca2+, a selective BAPTA-type synthetic receptor / host was integrated with a photoswitchable azobenzene motif, which upon photoirradiation would enhance (or diminish) the capacity to bind calcium upon acting on the conformation of the adjacent binding site, rendering it a stronger or weaker binder.
