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BAY 091

Cat. No. 7673 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective PIP4K2A inhibitor
Chemical Name: (R)-2-((3-Cyano-2-(2'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)-1,7-naphthyridin-4-yl)amino)butanoic acid
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAY 091

BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC50 values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.

Technical Data for BAY 091

M. Wt 440.48
Formula C26H21FN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2922280-34-8
PubChem ID 155884467
InChI Key DVIVLYHDLNAXAT-OAQYLSRUSA-N
Smiles CC[C@H](C(O)=O)NC1=C(C(C2=CC=C(C3=C(C(C)=CC=C3)F)C=C2)=NC4=C1C=CN=C4)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 091

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.02 50 with gentle warming

Preparing Stock Solutions for BAY 091

The following data is based on the product molecular weight 440.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.54 mL 22.7 mL 45.41 mL
2.5 mM 0.91 mL 4.54 mL 9.08 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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References for BAY 091

References are publications that support the biological activity of the product.

Wortmann et al (2021) Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 64 15883 PMID: 34699202

If you know of a relevant reference for BAY 091, please let us know.

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Citations for BAY 091

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