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Submit ReviewBMX-IN-1
Description: Potent and irreversible BMX inhibitor
Chemical Name: N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Purity: ≥98% (HPLC)
Biological Activity for BMX-IN-1
BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.
External Portal Information for BMX-IN-1
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.
Technical Data for BMX-IN-1
| M. Wt | 524.59 |
| Formula | C29H24N4O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1431525-23-3 |
| PubChem ID | 71576693 |
| InChI Key | SFMJNHNUOVADRW-UHFFFAOYSA-N |
| Smiles | CC(C=C5)=C(NC(C=C)=O)C=C5N(C2=C(C=C3)C=NC1=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C12)C3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMX-IN-1
References for BMX-IN-1
References are publications that support the biological activity of the product.
Liu et al (2013) Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 8 1423 PMID: 23594111
Li et al (2017) BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 8 49238 PMID: 28514765
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Keywords: BMX-IN-1, BMX-IN-1 supplier, BMX, inhibitors, inhibits, nonreceptor, tyrosine, kinase, potent, irreversible, selective, Other, Kinases, 5123, Tocris Bioscience
1 Citation for BMX-IN-1
Citations are publications that use Tocris products. Selected citations for BMX-IN-1 include:
Rudolf et al (2021) Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening. Cell Rep 35 109233 PMID: 34133938
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