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Submit ReviewBryostatin 2
Discontinued Product
This product has been withdrawn from sale and is superseded by Bryostatin 1 (Cat. No. 2383)
Description: Protein kinase C activator
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester
Purity: ≥98%
Biological Activity for Bryostatin 2
Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.
Technical Data for Bryostatin 2
| M. Wt | 863 |
| Formula | C45H66O16 |
| Storage | Store at -20°C |
| Purity | ≥98% |
| CAS Number | 87745-28-6 |
| PubChem ID | 6438131 |
| InChI Key | LIPGUSBNMQRYNL-IZBIBDMISA-N |
| Smiles | O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bryostatin 2
References for Bryostatin 2
References are publications that support the biological activity of the product.
Dale et al (1989) Comparison of effects of bryoSTAT 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res. 49 3242 PMID: 2720677
Dell'Aquila et al (1988) Differential effects of bryoSTAT and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res. 48 3702 PMID: 3132318
Jalava et al (1990) Effects of bryoSTAT 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Cancer Res. 50 3422 PMID: 2334938
Kedei et al (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol. 85 313 PMID: 23146662
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Keywords: Bryostatin 2, Bryostatin 2 supplier, Protein, Kinase, C, PKC, activators, analogue, Bryostatin, 1, antitumor, macrocyclic, lactone, arachidonic, acid, release, 5237, Tocris Bioscience
Citations for Bryostatin 2
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