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Submit ReviewBTD S-sulfenic acid probe
Description: Chemoproteomic reagent for targeting S-sulfenic acids on SulfenQ platform, alkyne handle for click chemistry
Chemical Name: 1-(4-Pentyn-1-yl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide
Purity: ≥98% (HPLC)
Biological Activity for BTD S-sulfenic acid probe
BTD S-sulfenic acid probe is a nucleophilic fragment that can selectively modify sulfenic acid residues in proteins, and can be used as a tool to identify ligandable S-sulfenation sites. Covalently modifies oxidized cysteines on proteins. Quantitatively labels hyper-reactive sulfenic acids at low BTD concentrations, less reactive sites exhibit concentration-dependent increases in probe labeling. Incorporates an alkyne handle for click chemistry and chemoproteomic profiling.
Technical Data for BTD S-sulfenic acid probe
| M. Wt | 263.31 |
| Formula | C13H13NO3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2095485-22-4 |
| PubChem ID | 155551901 |
| InChI Key | GSSKUKMXWRNMFK-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(N(S(=O)(C1)=O)CCCC#C)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BTD S-sulfenic acid probe
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.33 | 100 | |
| ethanol | 5.27 | 20 |
Preparing Stock Solutions for BTD S-sulfenic acid probe
The following data is based on the product molecular weight 263.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.8 mL | 18.99 mL | 37.98 mL |
| 5 mM | 0.76 mL | 3.8 mL | 7.6 mL |
| 10 mM | 0.38 mL | 1.9 mL | 3.8 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets for BTD S-sulfenic acid probe
References for BTD S-sulfenic acid probe
References are publications that support the biological activity of the product.
Fu et al (2023) Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat.Chem.Biol. 19 1309 PMID: 37248412
Gupta et al (2017) Diverse redoxome reactivity profiles of carbon nucleophiles. J.Am.Chem.Soc. 139 5588 PMID: 28355876
If you know of a relevant reference for BTD S-sulfenic acid probe, please let us know.
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Keywords: BTD S-sulfenic acid probe, BTD S-sulfenic acid probe supplier, BTD, sulfenic, acid, probe, sulfenation, cysteine, alkyne, handle, click, chemistry, s-sulfenation, Biochemicals, and, Molecular, Biology, 8059, Tocris Bioscience
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