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Chem-CLIP control probe

Cat. No. 7769 Submit a Review Datasheet / COA / SDS
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Description: Control probe for Chem-CLIP experiments
Chemical Name: 3-(3-Butyn-1-yl)-N-propyl-3H-diazirine-3-propanamide
Purity: ≥95% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Chem-CLIP control probe

Chem-CLIP (chemical cross-linking and isolation by pull-down) control probe is a control probe for Chem-CLIP experiments.

Technical Data for Chem-CLIP control probe

M. Wt 207.28
Formula C11H17N3O
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2767983-73-1
PubChem ID 170526590
InChI Key CYVAYGJWWZAPCE-UHFFFAOYSA-N
Smiles O=C(CCC1(CCC#C)N=N1)NCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Chem-CLIP control probe

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.73 100

Preparing Stock Solutions for Chem-CLIP control probe

The following data is based on the product molecular weight 207.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.82 mL 24.12 mL 48.24 mL
5 mM 0.96 mL 4.82 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.82 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Chem-CLIP control probe

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Chem-CLIP control probe

References are publications that support the biological activity of the product.

Bush et al (2021) Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models. Sci.Transl.Med. 13 eabd5991 PMID: 34705518

Tong et al (2023) Transcriptome-wide mapping of small-molecule RNA-binding sites in cells informs an isoform-specific degrader of QSOX1 mRNA. J.Am.Chem.Soc. 145 9364 PMID: 37058601

If you know of a relevant reference for Chem-CLIP control probe, please let us know.

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Citations for Chem-CLIP control probe

Citations are publications that use Tocris products.

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