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Description: Potent TAOK inhibitor
Chemical Name: N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for CP 43
CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.
Compound Libraries for CP 43
CP 43 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for CP 43
| M. Wt | 384.47 |
| Formula | C25H24N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 850467-66-2 |
| PubChem ID | 46673962 |
| InChI Key | WQKXOAJVNFOHNZ-UHFFFAOYSA-N |
| Smiles | O=C(NC1CCCC2=CC=CC=C12)CNC(C3=CC=C(C4=CC=CC=C4)C=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 43
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.45 | 100 | |
| ethanol | 7.69 | 20 |
Preparing Stock Solutions for CP 43
The following data is based on the product molecular weight 384.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13 mL | 26.01 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for CP 43
References for CP 43
References are publications that support the biological activity of the product.
Koo et al (2017) Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 16 2410 PMID: 28830982
Giacomini et al (2018) A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 6 37 PMID: 29730992
If you know of a relevant reference for CP 43, please let us know.
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Keywords: CP 43, CP 43 supplier, CP43, TAOK, TAOK1, TAOK2, TAO, thousand, and, one, amino, acid, kinase, inhibitors, inhibits, potent, JNK, activation, Other, Kinases, JNK/c-jun, 6558, Tocris Bioscience
1 Citation for CP 43
Citations are publications that use Tocris products. Selected citations for CP 43 include:
Smita et al (2021) TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell 56 3321-3333.e5 PMID: 34879262
Do you know of a great paper that uses CP 43 from Tocris? Please let us know.
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