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CRT 0066854 hydrochloride

Cat. No. 5922 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PKCι and PKCζ inhibitor
Chemical Name: (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.

Compound Libraries for CRT 0066854 hydrochloride

CRT 0066854 hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for CRT 0066854 hydrochloride

M. Wt 488.48
Formula C24H25N5S.2HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2250019-91-9
PubChem ID 131954580
InChI Key NYUVOWXZRBZQBA-NTEVMMBTSA-N
Smiles N[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(SC3=NC(C5=CC=NC=C5)=N2)CCCC4.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CRT 0066854 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 48.85 100
DMSO 48.85 100

Preparing Stock Solutions for CRT 0066854 hydrochloride

The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets for CRT 0066854 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for CRT 0066854 hydrochloride

References are publications that support the biological activity of the product.

Linch et al (2014) Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35 396 PMID: 24072773

Kjaer et al (2013) Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem.J. 451 329 PMID: 23418854

If you know of a relevant reference for CRT 0066854 hydrochloride, please let us know.

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1 Citation for CRT 0066854 hydrochloride

Citations are publications that use Tocris products. Selected citations for CRT 0066854 hydrochloride include:

Jann N et al (2021) Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities. Cell Rep 37 110054 PMID: 34818553

Do you know of a great paper that uses CRT 0066854 hydrochloride from Tocris? Please let us know.

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