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Submit ReviewCyclapolin 9
Description: Selective, ATP-competitive PLK1 inhibitor
Chemical Name: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide
Purity: ≥98% (HPLC)
Biological Activity for Cyclapolin 9
Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM).
Technical Data for Cyclapolin 9
| M. Wt | 307.21 |
| Formula | C9H4F3N3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 40533-25-3 |
| PubChem ID | 2779952 |
| InChI Key | FHFLXKUKCSDMLD-UHFFFAOYSA-N |
| Smiles | [O-][N+]2=C(C(N)=O)SC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cyclapolin 9
References for Cyclapolin 9
References are publications that support the biological activity of the product.
Taylor et al (2008) Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 153 S55 PMID: 18037921
McInnes et al (2006) Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol. 2 608
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Keywords: Cyclapolin 9, Cyclapolin 9 supplier, Selective, ATP-competitive, PLK1, inhibitors, inhibits, Polo-like, Kinase, Kinases, Cyclapolin9, Mitosis, 3116, Tocris Bioscience
1 Citation for Cyclapolin 9
Citations are publications that use Tocris products. Selected citations for Cyclapolin 9 include:
Cozzoli et al (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A 36 1623 PMID: 22432643
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.