Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCZC 24832
Description: Selective inhibitor of PI 3-kinase γ
Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for CZC 24832
CZC 24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for CZC 24832
| M. Wt | 364.4 |
| Formula | C15H17FN6O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1159824-67-5 |
| PubChem ID | 42623951 |
| InChI Key | RXRZPHQBTHQXSV-UHFFFAOYSA-N |
| Smiles | NC2=NN1C=C(C3=CN=CC(S(NC(C)(C)C)(=O)=O)=C3)C=C(F)C1=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CZC 24832
References for CZC 24832
References are publications that support the biological activity of the product.
Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576 PMID: 22544264
View Related Products by Target
View Related Products by Product Action
Keywords: CZC 24832, CZC 24832 supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, PI, 3-Kinase, Inositol, Lipids, 4674, Tocris Bioscience
Citations for CZC 24832
Citations are publications that use Tocris products.
Currently there are no citations for CZC 24832.
Reviews for CZC 24832
There are currently no reviews for this product. Be the first to review CZC 24832 and earn rewards!
Have you used CZC 24832?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image