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Submit ReviewDC-Cholesterol hydrochloride
Description: Cationic cholesterol derivative
Chemical Name: (3β)-3-[N-[2-(Dimethylamino)ethyl]carbamate cholest-5-en-3-ol hydrochloride
Purity: ≥95% (HPLC)
Biological Activity for DC-Cholesterol hydrochloride
DC-Cholesterol hydrochloride is a cationic cholesterol derivative for use as a liposomal transfection reagent. Combines with the 'helper lipid' DOPE (Cat. No. 7175) after sonication or microfluidization to form unilamellar liposomes. Can be used in vitro and in vivo for transfer of nucleic acids, protein complexes, or other small molecule complexes into tissues, tumors and cells.
Technical Data for DC-Cholesterol hydrochloride
| M. Wt | 537.27 |
| Formula | C32H56N2O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 166023-21-8 |
| PubChem ID | 16219102 |
| InChI Key | ISXSJGHXHUZXNF-LXZPIJOJSA-N |
| Smiles | [H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3(CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@@]4([C@]3(CC[C@]12C)[H])C)[H])[H].Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DC-Cholesterol hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.69 | 5 with sonication | |
| ethanol | 10.75 | 20 |
Preparing Stock Solutions for DC-Cholesterol hydrochloride
The following data is based on the product molecular weight 537.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.31 mL | 46.53 mL | 93.06 mL |
| 1 mM | 1.86 mL | 9.31 mL | 18.61 mL |
| 2 mM | 0.93 mL | 4.65 mL | 9.31 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
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Product Datasheets for DC-Cholesterol hydrochloride
References for DC-Cholesterol hydrochloride
References are publications that support the biological activity of the product.
Li et al (1996) DC-Chol lipid system in gene transfer. J.Control.Release 39 373
If you know of a relevant reference for DC-Cholesterol hydrochloride, please let us know.
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Citations for DC-Cholesterol hydrochloride
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