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Submit ReviewDisulfide biotin azide
Description: Azide-activated biotinylation reagent; labels alkyne moieties via copper-catalyzed click chemistry
Chemical Name: N-(24-Azido-12,20-dioxo-3,6,9-trioxa-16,17-dithia-13,21-diazatetracosyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
Purity: ≥90% (HPLC)
Biological Activity for Disulfide biotin azide
Disulfide Biotin Azide is an azide-activated cleavable (disulphide) biotin probe. It allows the biotinylation of molecules containing alkyne moiety via copper-catalyzed click chemistry reactions.
Technical Data for Disulfide biotin azide
| M. Wt | 692.91 |
| Formula | C27H48N8O7S3 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 2866429-93-6 |
| PubChem ID | 102514779 |
| InChI Key | FVMIKTRZXCSAEY-MCEYFSPLSA-N |
| Smiles | O=C(N1)N[C@]([C@]1([H])CS2)([H])[C@@H]2CCCCC(NCCOCCOCCOCCC(NCCSSCCC(NCCCN=[N+]=[N-])=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Disulfide biotin azide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.86 | 20 |
Preparing Stock Solutions for Disulfide biotin azide
The following data is based on the product molecular weight 692.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 7.22 mL | 36.08 mL | 72.16 mL |
| 1 mM | 1.44 mL | 7.22 mL | 14.43 mL |
| 2 mM | 0.72 mL | 3.61 mL | 7.22 mL |
| 10 mM | 0.14 mL | 0.72 mL | 1.44 mL |
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Product Datasheets for Disulfide biotin azide
References for Disulfide biotin azide
References are publications that support the biological activity of the product.
Eisen et al (2020) MicroRNAs cause accelerated decay of short-tailed target mRNAs. Mol.Cell 77 775 PMID: 31902668
Chen et al (2020) Design, optimization, and study of small molecules that target Tau pre-mRNA and affect splicing. J.Am.Chem.Soc. 142 8706 PMID: 32364710
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Keywords: Disulfide biotin azide, Disulfide biotin azide supplier, Click, Chemistry, biotinylation, labeling, labelling, azide, alkyne, copper, Cu, catalyzed, click, chemistry, Biochemicals, and, Molecular, Biology, 7768, Tocris Bioscience
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