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Submit Review(±)-α-Lipoic acid
Discontinued Product
7044 has been discontinued.
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Description: Liquid-liquid phase separated condensate modifier; reduces stress granule formation
Chemical Name: 1,2-Dithiolane-3-pentanoic acid
Purity: ≥98% (HPLC)
Biological Activity for (±)-α-Lipoic acid
(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.
Technical Data for (±)-α-Lipoic acid
| M. Wt | 206.32 |
| Formula | C8H14O2S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1077-28-7 |
| PubChem ID | 864 |
| InChI Key | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| Smiles | OC(=O)CCCCC1CCSS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-α-Lipoic acid
References for (±)-α-Lipoic acid
References are publications that support the biological activity of the product.
Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235
Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628
Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed
Dong et al (2020) Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 108 1711 PMID: 32640500
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