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Submit ReviewDLin-MC3-DMA
Description: Component of lipid nanoparticles (LNPs); ionizable cationic lipid
Chemical Name: (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
Purity: ≥95% (HPLC)
Biological Activity for DLin-MC3-DMA
DLin-MC3-DMA is an ionizable cationic lipid (pKa = 6.44), used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for delivering cargos such as oligonucleotides into living cells. DLin-MC3-DMA can protect negatively charged cargos and facilitate their cytosolic transport.
For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.
Technical Data for DLin-MC3-DMA
| M. Wt | 642.09 |
| Formula | C43H79NO2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1224606-06-7 |
| InChI Key | NRLNQCOGCKAESA-KWXKLSQISA-N |
| Smiles | C(OC(CCCN(C)C)=O)(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DLin-MC3-DMA
| Solubility | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL) |
Product Datasheets for DLin-MC3-DMA
References for DLin-MC3-DMA
References are publications that support the biological activity of the product.
Han et al (2021) An ionizable lipid toolbox for RNA delivery. Nat.Commun 12 7233 PMID: 34903741
Semple et al (2010) Rational design of cationic lipids for siRNA delivery. Nat.Biotechnol 28 172 PMID: 20081866
Jayaraman et al (2012) Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew.Chem.Int.Ed.Engl 51 8529 PMID: 22782619
If you know of a relevant reference for DLin-MC3-DMA, please let us know.
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Keywords: DLin-MC3-DMA, DLin-MC3-DMA supplier, DLinMC3DMA, unsaturated, ionizable, cationic, lipid, nanoparticles, LNP, cargo, delivery, cytosolic, transport, Biochemicals, and, Molecular, Biology, Lipid, Nanoparticles, 7946, Tocris Bioscience
Citations for DLin-MC3-DMA
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