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Submit ReviewDMG-PEG 2000
Description: PEGylated myristoyl diglyceride; commonly used in the formation of lipid nanoparticles (LNPs)
Chemical Name: 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
Purity: ≥90% (HPLC)
Biological Activity for DMG-PEG 2000
DMG-PEG 2000 is a PEGylated myristoyl diglyceride consisting of one unbranched PEG 2000 chain and two saturated fatty acid chains (C14:0) covalently attached to a glycerol. DMG-PEG 2000 is commonly used in the formation of lipid nanoparticles (LNPs) and liposomes to prevent serum protein adsorption, nanoparticle aggregation and increase in vivo circulation time. DMG-PEG 2000 is a component of LNPs which can be used for delivery of RNA-based vaccines or mRNA therapeutics.
For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.
Technical Data for DMG-PEG 2000
| Formula | (C2H4O)nC32H62O5 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 160743-62-4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DMG-PEG 2000
| Solubility | Soluble to 10 mg/ml in ethanol and to 10 mg/ml in chloroform |
Product Datasheets for DMG-PEG 2000
References for DMG-PEG 2000
References are publications that support the biological activity of the product.
Cheng et al (2018) Dendrimer-based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I. Adv.Mater. 30 e1805308 PMID: 30368954
Zhang et al (2020) Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing. Sci.Adv. 6 eabc2315 PMID: 32937374
If you know of a relevant reference for DMG-PEG 2000, please let us know.
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