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Submit ReviewDSPE-PEG 2000 Maleimide
Description: PEGylated DSPE with a maleimide reactive group
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]
Purity: ≥90% (HPLC)
Biological Activity for DSPE-PEG 2000 Maleimide
DSPE-PEG 2000 Maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (Mr 2000) with a maleimide-terminated end for onward chemistry. It is commonly used to synthesize antibody-coupled liposomes and lipid nanoparticles. It has been used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo.
Technical Data for DSPE-PEG 2000 Maleimide
| Formula | (C2H4O)nC51H91N3O13P.NH4 or Na |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DSPE-PEG 2000 Maleimide
| Solubility | Soluble to 10 mg/ml in ethanol with gentle warming and to 10 mg/ml in chloroform |
Product Datasheets for DSPE-PEG 2000 Maleimide
References for DSPE-PEG 2000 Maleimide
References are publications that support the biological activity of the product.
Ishida et al (1999) A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 460 129 PMID: 10571074
Rurik et al (2022) CAR T cells produced in vivo to treat cardiac injury. Science 375 91 PMID: 34990237
Herrera-Barrera et al (2023) Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci.Adv. 9 eadd4623 PMID: 36630502
If you know of a relevant reference for DSPE-PEG 2000 Maleimide, please let us know.
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