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Submit ReviewGlycyl-H 1152 dihydrochloride
Description: Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Glycyl-H 1152 dihydrochloride
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
Technical Data for Glycyl-H 1152 dihydrochloride
| M. Wt | 449.4 |
| Formula | C18H24N4O3S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 913844-45-8 |
| PubChem ID | 56972177 |
| InChI Key | ILDBNQGLZFSHQZ-UTLKBRERSA-N |
| Smiles | CC1=CN=CC2=C1C(S(N3CCCN(C(CN)=O)C[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Glycyl-H 1152 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.94 | 100 | |
| DMSO | 22.47 | 50 |
Preparing Stock Solutions for Glycyl-H 1152 dihydrochloride
The following data is based on the product molecular weight 449.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.13 mL | 22.25 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for Glycyl-H 1152 dihydrochloride
References for Glycyl-H 1152 dihydrochloride
References are publications that support the biological activity of the product.
Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245 PMID: 16213195
If you know of a relevant reference for Glycyl-H 1152 dihydrochloride, please let us know.
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Keywords: Glycyl-H-1152 dihydrochloride, Glycyl-H-1152 dihydrochloride supplier, selective, Rho-Associated, Coiled-Coil, Kinases, ROCK, p160ROCK, ROK, Rho-Kinases, Rho-kinases, 2485, Tocris Bioscience
4 Citations for Glycyl-H 1152 dihydrochloride
Citations are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:
Siegel et al (2010) Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 19 3320 PMID: 20542987
Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349
Sadaie et al (2015) Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26 2971 PMID: 26133385
Lawrence et al (2015) Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep 5 9092 PMID: 25766625
Do you know of a great paper that uses Glycyl-H 1152 dihydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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