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Submit Review2-Hydroxypropyl-β-cyclodextrin
Description: Solubilization agent
Alternative Names: HBC,Hydroxypropyl-β-cyclodextrin
Biological Activity for 2-Hydroxypropyl-β-cyclodextrin
The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.
Technical Data for 2-Hydroxypropyl-β-cyclodextrin
| M. Wt | 1400 |
| Formula | (C6H9O5)7(C3H7O)n |
| Storage | Store at RT |
| CAS Number | 128446-35-5 |
| PubChem ID | 44134771 |
| InChI Key | BZRWCHBEBFPRGF-UHFFFAOYSA-N |
| Smiles | O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-Hydroxypropyl-β-cyclodextrin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 140 | 100 |
Preparing Stock Solutions for 2-Hydroxypropyl-β-cyclodextrin
The following data is based on the product molecular weight 1400. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.43 mL |
| 10 mM | 0.07 mL | 0.36 mL | 0.71 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
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Product Datasheets for 2-Hydroxypropyl-β-cyclodextrin
References for 2-Hydroxypropyl-β-cyclodextrin
References are publications that support the biological activity of the product.
Frijlink (1991) The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 8 380 PMID: 2052529
Pitha et al (1986) Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol. 29 73
If you know of a relevant reference for 2-Hydroxypropyl-β-cyclodextrin, please let us know.
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Keywords: Hydroxypropyl-b-cyclodextrin, Hydroxypropyl-b-cyclodextrin supplier, Solubilization, agent, Reagents, cyclodextrin, Hydroxypropyl-beta-cyclodextrin, Hydroxypropyl-β-cyclodextrin, HBC, Hydroxypropyl-b-cyclodextrin, Biochemicals, and, Molecular, Biology, 0708, Tocris Bioscience
2 Citations for 2-Hydroxypropyl-β-cyclodextrin
Citations are publications that use Tocris products. Selected citations for 2-Hydroxypropyl-β-cyclodextrin include:
Marco et al (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nat Commun 7 12620 PMID: 27646867
Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Proc Natl Acad Sci U S A 107 733 PMID: 22554617
Do you know of a great paper that uses 2-Hydroxypropyl-β-cyclodextrin from Tocris? Please let us know.
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