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Submit ReviewLithium carbonate
Description: Mood stabilizer; inhibits GSK-3 in vivo
Chemical Name: Carbonic acid dilithium salt
Biological Activity for Lithium carbonate
Lithium carbonate is a mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.
Technical Data for Lithium carbonate
| M. Wt | 73.89 |
| Formula | Li2CO3 |
| Storage | Store at RT |
| CAS Number | 554-13-2 |
| PubChem ID | 11125 |
| InChI Key | XGZVUEUWXADBQD-UHFFFAOYSA-L |
| Smiles | [Li+].[Li+].[O-]C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Lithium carbonate
References for Lithium carbonate
References are publications that support the biological activity of the product.
Lenox and Hahn (2000) Overview of the mechanism of action of Li in the brain: fifty-year update. J.Clin.Psychiatry 61 5 PMID: 10826655
Gould et al (2004) In vivo evidence in the brain for Li inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29 32 PMID: 12942141
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Keywords: Lithium carbonate, Lithium carbonate supplier, Mood, stabilizers, sodium, potassium, Na+/K+, ATPase, pumps, bipolar, Glycogen, Synthase, Kinase, 3, 4740, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Lithium carbonate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 Citation for Lithium carbonate
Citations are publications that use Tocris products. Selected citations for Lithium carbonate include:
Irene et al (2018) Automatic quantification of juvenile zebrafish aggression. J Neurosci Methods 296 23-31 PMID: 29274793
Reviews for Lithium carbonate
Average Rating: 5 (Based on 1 Review.)
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Li2CO3 prolongs cardiac action potential duration.
By
Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Ventricular cardiomyocytes
Guinea pig ventricular cardiomyocytes were patched and stimulated at a 1 Hz frequency to record action potentials before and after Li2CO3 (10 and 30 µM). Li2CO3 significantly prolonged action potential duration at 20% and 90% repolarization levels.
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Pathways for Lithium carbonate
