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LYN 1604 dihydrochloride

Cat. No. 6617 Submit a Review Datasheet / COA / SDS
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Description: Potent UNC-51-like kinase 1 (ULK1) agonist
Chemical Name: 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LYN 1604 dihydrochloride

LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.

Technical Data for LYN 1604 dihydrochloride

M. Wt 657.54
Formula C33H43Cl2N3O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2310109-38-5
PubChem ID 131954512
InChI Key GZCBLOPFZPJUOQ-UHFFFAOYSA-N
Smiles O=C(CN(CC(C)C)CC(C)C)N1CCN(CC(C2=CC=C(C=C2Cl)Cl)OCC3=CC4=C(C=CC=C4)C=C3)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LYN 1604 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.58 10

Preparing Stock Solutions for LYN 1604 dihydrochloride

The following data is based on the product molecular weight 657.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.21 mL 76.04 mL 152.08 mL
0.5 mM 3.04 mL 15.21 mL 30.42 mL
1 mM 1.52 mL 7.6 mL 15.21 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

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Product Datasheets for LYN 1604 dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for LYN 1604 dihydrochloride

References are publications that support the biological activity of the product.

Zhang et al (2021) ULK1 suppresses osteoclast differentiation and bone resorption via inhibiting Syk-JNK through DOK3. Oxid.Med.Cell Longev. 2021 2896674 PMID: 34820053

Zhang et al (2018) UNC-51-like Kinase 1: from an autophagic initiator to multifunctional drug target. J.Med.Chem. 61 6491 PMID: 29509411

Zhang et al (2017) Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem.Sci. 8 2687 PMID: 28553505

If you know of a relevant reference for LYN 1604 dihydrochloride, please let us know.

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Citations for LYN 1604 dihydrochloride

Citations are publications that use Tocris products.

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