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ML 281

Cat. No. 4880 1 Citation Submit a Review Datasheet / COA / SDS
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Description: STK33 inhibitor
Chemical Name: N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 281

ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.

Compound Libraries for ML 281

ML 281 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 281

M. Wt 389.47
Formula C22H19N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1404437-62-2
PubChem ID 53377448
InChI Key HWOYIOLMBQSTQS-UHFFFAOYSA-N
Smiles CC(C)C1=CC(C2=NC(C=CC=C3)=C3NC2=O)=C(NC(C4=CC=CS4)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 281

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.95 100

Preparing Stock Solutions for ML 281

The following data is based on the product molecular weight 389.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for ML 281

References are publications that support the biological activity of the product.

Weiwer et al (2012) A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 3 1034 PMID: 23256033

If you know of a relevant reference for ML 281, please let us know.

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Keywords: ML 281, ML 281 supplier, ML281, STK33, kinases, inhibitors, inhibits, selective, Other, Kinases, 4880, Tocris Bioscience

1 Citation for ML 281

Citations are publications that use Tocris products. Selected citations for ML 281 include:

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

Do you know of a great paper that uses ML 281 from Tocris? Please let us know.

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